Drug Discovery and Development

Going from compound screening or drug discovery to an actual working and safe drug to sell on the market takes a lot of research and clinical trials. These studies must be performed under strict NDAs, regulations and guidelines. We are clear and transparant in what is ISO accredited and what we will deliver (as a guarantee on the quotation) and when we will deliver the data. Since several years we are a well known outsourcing laboratory for several leading pharmaceutical companies.

Testing services, validation studies, quality controls, Standard Operating Procedures (SOPs), and our ISO 17025 accreditation are part of our quality system. 

 

Laboratory Services for Pharmacogenetics and Drug Development:

  • Whole Genome Sequencing
    • Resequencing for SNP discovery, small InDels and variant analysis
  • Whole Exome Sequencing
    • Mouse or human all exon sequencing
  • Targeted sequencing
  • Transcriptome sequencing
    • Expression analysis
    • mRNA (re)sequencing for cSNP detection or alternative splicing
    • DeepCAGE/NanoCAGE sequencing
    • miRNA/small RNA discovery and quantification
    • rRNA depletion sample preparation
  • Metagenome sequencing
  • Antibody sequencing with single molecule long read sequencer
  • Microarray-based DNA Methylation profiling using the 450K
  • High throughout microarray-based gene expression analysis for standard and specialized protocols:
    • FFPE samples
    • Low yield RNA samples (from 500pg RNA) for Illumina/Affymetrix arrays
    • Globin reduction protocols for the HumanHT-12 BeadChip
               

 

Technologies Available for the Pharmaceutical Industry and Research Departments:

  • Next Generation Sequencing with the Illumina HiSeq 2500
  • Strand specific RNA sequencing and Exome Seq on our Ion Proton Platform
  • Targeted Sequencing with Agilent's SureSelect
  • Third Generation Single Molecule Sequencing with the PacBio RS II
  • Gene expression profiling with Illumina (HumanHT-12/MouseRef-8/MouseWG-6)
  • Gene expression profiling with Affymetrix GeneTitan plates 
  • DNA methylation analysis with the Illumina HumanMethylation450K BeadChip