Genotyping

ServiceXS has ample experience with SNP discovery, genotyping and screening at the same time. We are well equipped to guide you in the diverse and fast developing SNP field. Scoring 100,000 SNPs in 10 samples requires a completely different approach than scoring 10 SNPs in 100,000 samples.

• Custom Genotyping
• Illumina's GoldenGate and Infinium assays
• Affymetrix Axiom technology
• Fixed Panel Genotyping
• Illumina's catalogue BeadChips
• Affymetrix Axiom fixed catalogue arrays
• CNV analysis
• Fluidigm (high throughput real time PCR)
• Illumina's catalogue BeadChips
• SNP Discovery
• Illumina HiSeq sequencing

Illumina Custom genotyping (array based)
Illumina's GoldenGate technology is a customized genotyping service in our portfolio that provides solutions for a relatively low small number of SNPs per sample. The Infinium iSelect is ideal for larger projects. ServiceXS has become expert in both of these services. 

Illumina's GoldenGate assay is most suitable for medium to small sized projects (96 samples and more) and SNPs (between 96 and 1,536). For larger projects and more SNPs to be analyzed, we recommend Illumina's Infinium custom iSelect.

Illumina Fixed panel genotyping (array based)
Illumina has fixed panels/catalogue BeadChips for different organisms (bovine, canine, ovine, porcine and maize) as well as different human panels, supporting a variety of applications such as candidate-gene studies in cancer, cardiovascular disease and more. For human research, Illumina also developed arrays specific for cytogenetic analysis and/or CNV and LOH analysis. BeadChips are starting from 300,000 markers per sample to 2.5 million and the number is increasing still.

Affymetrix Axiom technology - custom and fixed panel genotyping (array based)
Recently, the Axiom technology was added to our genotyping portfolio. With GeneTitan plate formats our flexibility in genotyping increases. Affymetrix has pre-designed arrays available with the up-to-date content available from GWAS studies. We also offer custom genotyping on this platform. The fully customizable array plate can accomodate between 1,500 - 2.6 million SNPs.

CNV analysis (Fluidigm Real time PCR)
Fluidigm's Dynamic Array with integrated fluidic circuits (IFCs) is suitable for copy number variation (CNV) studies. Using Fluidigms IFCs and Real-Time PCR methodology ServiceXS offers high throughput services with an extremely accurate quantification of CNV. In one single panel on the Dynamic Array IFC you can determine the difference between four and five copies.

SNP discovery (sequencing based)
With Illumina and PacBio next generation sequencing technology, ServiceXS can offer you SNP discovery and genotyping for any organism. With extensive data analysis, we can offer you customized production of specific SNP lists that are ready to use for the synthesis of custom genotyping assays for follow-up experiments.