DNA methylation is an important regulator in gene transcription and has been implicated in the etiology of many diseases among others cancer. Methylation studies are interesting follow-up studies for gene expression experiments to better understand gene regulation.
ServiceXS offers different technologies to research epigenetics. Here we focus on Illumina's microarray: the Illumina HumanMethylation450K BeadChip. This new and improved version of the 27K BeadChip is an excellent tool for quantitative methylation measurement of large sample sets at single CpG site level.
We provide services for project sizes of 48 samples (and multiples there of). For introduction or pilot studies, ServiceXS will make an exception and offer services for 24-sample projects. We offer the experiments with bisulfite conversion service and under the ISO 17025 accreditation scope.
Promotion - Limited
We have a limited number of BeadChips available at promotional prices. ServiceXS works on a first come, first serve basis. Contact us for a quotation!
450K Infinium Methylation BeadChip - BeadChip information
This BeadChip allows you to interrogate over 450,000 methylation sites at a single nucleotide resolution. It contains 90% of the HumanMethylation27 BeadChip, and is ideal in combination with the gene expression BeadChip. Additional high value content selected by experts include: CpG islands and shores, CpG sites outside of CpG islands, non-CpG methylated sites, sites found to be differentially methylated in tumor versus normal (multiple forms of cancer) and across several tissue types, CpG islands of coding regions, miRNA promotor regions, and disease associated regions through GWAS.
Benefits of the Illumina's Infinium assay is that you do not need Me-DIP (methylated DNA immunoprecipitation) and the coverage of the RefSeq genes, promoter- 5'- and 3'-regions, is without bias towards those lacking CpG islands.
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