Methylation BeadChips

With Methylation profiling with the Illumina BeadChips, you are able to quantiify methylation at the single CpG-site level, providing a high resolution for understanding epigenetic changes.

Available BeadChips of Illumina for methylation analysis: 

• the HumanMethylation27 BeadChip
• the 450K Infinium Methylation BeadChip.

450K Infinium Methylation BeadChip

This BeadChip allows you to interrogate over 450,000 methylation sites at a single nucleotide resolution. Benefits of this BeadChip is that you do not need Me-DIP (methylated DNA immunoprecipitation) and the coverage of the RefSeq genes, promoter- 5'- and 3'-regions, without bias towards those lacking CpG islands.

HumanMethylation27 BeadChip

This BeadChip enables the interrogation of 27,578 highly informative CpG sites per sample. This panel covers over 14,000 genes. Next to that, 254 assays analyze 110 miRNA promoters. This comes down to approximately 2 assays per CCDS genes and from 3-20 CpG sites for over 200 cancer-related and imprinted genes. The benefits of the HumanMethylation27 BeadChips are the resolution that enables single CpG-site analysis, high sample throughput with a 12 sample format per array, and a small amount of bisulfite treated DNA as input. With the high homology in genes that are represented on the HumanMethylation27 BeadChip and the HumanHT-12, Illumina offers you the possibility to integrate global methylation status with gene expression levels (over 12,700 genes are covered on the HT-12).

For more information on these services, please contact us to discuss your future project, or go to our inforequest Methylation form. ServiceXS offers methylation experiments from as low as €275,- per sample (for large sample sets), for orders that are placed before 1^st of December. Contact us for more information!